Liposomal gene delivery mediated by tissue-engineered scaffolds
Kulkarni, Mangesh Griser, Udo O'Brien, Timothy Pandit, Abhay
Kulkarni, Mangesh
Griser, Udo
O'Brien, Timothy
Pandit, Abhay
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http://hdl.handle.net/10379/1335
https://doi.org/10.13025/21664
https://doi.org/10.13025/21664
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Publication Date
2010-01-01
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Article
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Citation
Kulkarni, M., Greiser, U., O'Brien, T., & Pandit, A. Liposomal gene delivery mediated by tissue-engineered scaffolds. Trends in Biotechnology, 28(1), 28-36.
Abstract
In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as liposomes, which are the most widely researched versatile non-viral carriers, and tissue-engineered scaffolds with macrostructures of defined architecture comprised of natural or synthetic macromolecules. Here, we discuss the recent advances in liposomal gene delivery and the possible benefits of a combined liposome¿scaffold approach, such as long-term expression, enhanced stability, reduction in toxicity and ability to produce spatio-temporal expression patterns. This approach is generating significant impact in the field as a result of its potential for extended localised gene delivery for applications in a variety of clinical conditions.
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Publisher
Elsevier
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Attribution-NonCommercial-NoDerivs 3.0 Ireland