Publication

Campylobacter jejuni from patients with guillain-barre syndrome preferentially expresses a gd1a-like epitope

Nachamkin, I.
; 
Liu, J.
; 
Li, M.
; 
Ung, H.
; 
Moran, A. P.
; 
Prendergast, M. M.
; 
Sheikh, K.
Repository DOI
Publication Date
2002-09-01
Keywords
molecular mimicry, lipo-oligosaccharide, helicobacter-pylori, anti-gd1a antibody, gm1 ganglioside, lipopolysaccharides, gastroenteritis, infections, serotypes, strains
Type
Article
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Citation
Nachamkin, I. Liu, J.; Li, M.; Ung, H.; Moran, A. P.; Prendergast, M. M.; Sheikh, K. (2002). Campylobacter jejuni from patients with guillain-barre syndrome preferentially expresses a gd1a-like epitope. Infection and Immunity 70 (9), 5299-5303
Abstract
GM(1)- and GD(1a)-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barre syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GDla-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GDla like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.
Funder
Publisher
American Society for Microbiology
Publisher DOI
10.1128/iai.70.9.5299-5303.2002
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (1)