Nanosensitive optical coherence tomography to assess wound healing within the cornea
Lal, Cerine Alexandrov, Sergey Rani, Sweta Zhou, Yi Ritter, Thomas Leahy, Martin
Lal, Cerine
Alexandrov, Sergey
Rani, Sweta
Zhou, Yi
Ritter, Thomas
Leahy, Martin
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Publication Date
2020-05-01
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journal article
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Lal, Cerine, Alexandrov, Sergey, Rani, Sweta, Zhou, Yi, Ritter, Thomas, & Leahy, Martin. (2020). Nanosensitive optical coherence tomography to assess wound healing within the cornea. Biomedical Optics Express, 11(7), 3407-3422. doi: 10.1364/BOE.389342
Abstract
Optical coherence tomography (OCT) is a non-invasive depth resolved optical imaging modality, that enables high resolution, cross-sectional imaging in biological tissues and materials at clinically relevant depths. Though OCT offers high resolution imaging, the best ultra-high-resolution OCT systems are limited to imaging structural changes with a resolution of one micron on a single B-scan within very limited depth. Nanosensitive OCT (nsOCT) is a recently developed technique that is capable of providing enhanced sensitivity of OCT to structural changes. Improving the sensitivity of OCT to detect structural changes at the nanoscale level, to a depth typical for conventional OCT, could potentially improve the diagnostic capability of OCT in medical applications. In this paper, we demonstrate the capability of nsOCT to detect structural changes deep in the rat cornea following superficial corneal injury. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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Optical Society of America
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CC BY-NC-ND