Small lectin ligands as a basis for applications in glycoscience and glycomedicine
Murphy, Paul V.
Murphy, Paul V.
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Publication Date
2024-08-20
Type
journal article
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Citation
Murphy, Paul V., Dhara, Ashis, Fitzgerald, Liam S., Hever, Eoin, Konda, Saidulu, & Mandal, Kishan. (2024). Small lectin ligands as a basis for applications in glycoscience and glycomedicine. Chemical Society Reviews. doi: 10.1039/D4CS00642A
Abstract
Glycan recognition by lectins mediates important biological events. This Tutorial Review aims to introduce lectin–ligand interactions and show how these molecular recognition events inspire innovations such as: (i) glycomimetic ligands; (ii) multivalent ligand agonists/antagonists; (iii) ligands for precision delivery of therapies to cells, where therapies include vaccines, siRNA and LYTACs (iv) development of diagnostics. A small number of case studies are selected to demonstrate principles for development of new ligands for applications inspired by knowledge of natural glycan ligand structure and function.
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Publisher
Royal Society of Chemistry
Publisher DOI
10.1039/D4CS00642A
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Attribution 4.0 International