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New insights into the endophenotypic status of cognition in bipolar disorder: genetic modelling study of twins and siblings

Georgiades, A.
; 
Rijsdijk, F.
; 
Kane, F.
; 
Rebollo-Mesa, I.
; 
Kalidindi, S.
; 
Schulze, K. K.
; 
Stahl, D.
; 
Walshe, M.
; 
Sahakian, B. J.
; 
McDonald, C.
... show 3 more
Identifiers
http://hdl.handle.net/10379/11610
 https://doi.org/10.13025/27340
Publication Date
2016-03-17
Keywords
i disorder, 1st-degree relatives, premorbid iq, schizophrenia, memory, risk, heritability, depression, discordant, psychosis
Type
Article
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Citation
Georgiades, A. Rijsdijk, F.; Kane, F.; Rebollo-Mesa, I.; Kalidindi, S.; Schulze, K. K.; Stahl, D.; Walshe, M.; Sahakian, B. J.; McDonald, C.; Hall, M.-H.; Murray, R. M.; Kravariti, E. (2016). New insights into the endophenotypic status of cognition in bipolar disorder: genetic modelling study of twins and siblings. The British Journal of Psychiatry 208 (6),
Abstract
Background Twin studies have lacked statistical power to apply advanced genetic modelling techniques to the search for cognitive endophenotypes for bipolar disorder. Aims To quantify the shared genetic variability between bipolar disorder and cognitive measures. Method Structural equation modelling was performed on cognitive data collected from 331 twins/siblings of varying genetic relatedness, disease status and concordance for bipolar disorder. Results Using a parsimonious AE model, verbal episodic and spatial working memory showed statistically significant genetic correlations with bipolar disorder (r(g) = vertical bar 0.23 vertical bar-vertical bar 0.27 vertical bar), which lost statistical significance after covarying for affective symptoms. Using an ACE model, IQ and visual-spatial learning showed statistically significant genetic correlations with bipolar disorder (r(g) = vertical bar 0.51 vertical bar-vertical bar 1.00 vertical bar), which remained significant after covarying for affective symptoms. Conclusions Verbal episodic and spatial working memory capture a modest fraction of the bipolar diathesis. IQ and visual-spatial learning may tap into genetic substrates of non-affective symptomatology in bipolar disorder.
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Publisher
Royal College of Psychiatrists
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Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
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Externally hosted open access publications with University of Galway authors (2)