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Role of micro-rnas in breast cancer surgery

McAnena, P.
; 
Lowery, A.
; 
Kerin, M. J.
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Identifiers
http://hdl.handle.net/10379/12703
 https://doi.org/10.13025/27488
Publication Date
2018-01-01
Keywords
brca2 mutation carriers, lymph-node metastasis, circulating micrornas, tumor-suppressor, receptor status, nuclear export, up-regulation, early-stage, expression, cells
Type
journal article
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Citation
McAnena, P. Lowery, A.; Kerin, M. J. (2018). Role of micro-rnas in breast cancer surgery. British Journal of Surgery 105 (2), E19-E30
Abstract
Background: The management of breast cancer has changed dramatically in the molecular era. Micro-RNAs can contribute to multiple facets of cancer surgery. Methods: This narrative review, based on years of research on the role of micro-RNAs, focused on the potential of these small, robust RNAs to influence all aspects of breast cancer surgery. Results: Micro-RNAs have a potential role as biomarkers in the diagnosis, prognosis and evaluation of response to therapy in breast cancer. They may also contribute to future therapeutic strategies. Conclusion: The molecular era has changed understanding of cancer. Micro-RNAs have the potential for use in personalized cancer strategies.
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Publisher
Wiley-Blackwell
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Externally hosted open access publications with University of Galway authors (2)