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Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, t-maps, and individual mri data

Pezzoli, Stefania
; 
Emsell, Louise
; 
Yip, Sarah W.
; 
Dima, Danai
; 
Giannakopoulos, Panteleimon
; 
Zarei, Mojtaba
; 
Tognin, Stefania
; 
Arnone, Danilo
; 
James, Anthony
; 
Haller, Sven
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Identifiers
http://hdl.handle.net/10379/13464
 https://doi.org/10.13025/27508
Publication Date
2017-11-01
Keywords
bipolar disorder, meta-analysis, vbm, mri, white matter, voxel-based morphometry, brain structural-changes, corpus-callosum, default mode, i disorder, functional connectivity, schizophrenia, gray, psychosis, abnormalities
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Article
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Citation
Pezzoli, Stefania; Emsell, Louise; Yip, Sarah W. Dima, Danai; Giannakopoulos, Panteleimon; Zarei, Mojtaba; Tognin, Stefania; Arnone, Danilo; James, Anthony; Haller, Sven; Frangou, Sophia; Goodwin, Guy M.; McDonald, Colm; Kempton, Matthew J. (2017). Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, t-maps, and individual mri data. Neuroscience & Biobehavioral Reviews 84 , 162-170
Abstract
Converging evidence suggests that bipolar disorder (BD) is associated with white matter (WM) abnormalities. Meta-analyses of voxel based morphometry (VBM) data is commonly performed using published coordinates, however this method is limited since it ignores non-significant data. Obtaining statistical maps from studies (T-maps) as well as raw MRI datasets increases accuracy and allows for a comprehensive analysis of clinical variables. We obtained coordinate data (7-studies), T-Maps (12-studies, including unpublished data) and-raw MRI datasets (5-studies) and analysed the 24 studies using Seed-based d Mapping (SDM). A VBM analysis was conducted to verify the results in an independent sample. The meta-analysis revealed decreased WM volume in the posterior corpus callosum extending to WM in the posterior cingulate cortex. This region was significantly reduced in volume in BD patients in the independent dataset (p = 0.003) but there was no association with clinical variables. We identified a robust WM volume abnormality in BD patients that may represent a trait marker of the disease and used a novel methodology to validate the findings.
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Publisher
Elsevier BV
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)