6-iodonordihydrocapsaicin
Roche, Michelle Finn, David P.
Roche, Michelle
Finn, David P.
Identifiers
http://hdl.handle.net/10379/3943
https://doi.org/10.13025/22499
https://doi.org/10.13025/22499
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Publication Date
2009
Type
Book chapter
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Citation
Roche, M., Finn, D., Enna, S. J., & Bylund, D. B. (2009). 6-Iodonordihydrocapsaicin xPharm: The Comprehensive Pharmacology Reference (pp. 1-4). New York: Elsevier.
Abstract
6-Iodonordihydrocapsaicin was first synthesized by Giovanni Appendino at the Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences (DiSCAFF), Novara, Italy, while developing a series of halogenated derivatives of capsaicin (Appendino et al., 2003). This compound is a potent antagonist at the vanilloid VR-1 (TRPV1) receptor in several in vitro preparations. Its activity in vivo has not been examined. Recent evidence indicates that 6-iodonordihydrocapsaicin may also antagonize transient receptor potential channels of melastatin type 8 (TRPM8) (De Petrocellis et al., 2007)
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Attribution-NonCommercial-NoDerivs 3.0 Ireland