Publication

Chemical investigation of alkaloids from two haplosclerida sponges collected in Papua New Guinea

Besliu, Denis
Citation
Abstract
The phylum Porifera contributes immensely to the repertoire of marine natural products amassed to date. Regions of the Pacific Ocean where chemical diversity was not previously assessed were analysed and samples of various organisms including sponges were collected during the Tara Pacific expedition in 2016. Two sponges of the family Haplosclerida were selected for chemical investigation due to their chemical profile where mass spectrometry analysis showed the presence of alkaloids. Marine alkaloids are known to possess high bioactivity against various diseases. The objectives of this Masters are to isolate alkaloids from these sponges, elucidate their structures using NMR and test their bioactivity in terms of cytotoxicity and antioxidant activity. This investigation lead to the discovery of 4 known compounds, 1 new compound and left us with highly interesting NMR results for 2 further compounds.
Funder
Publisher
NUI Galway
Publisher DOI
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
CC BY-NC-ND 3.0 IE