Mesenchymal stem cells: key players in cancer progression
Ridge, Sarah M. ; Sullivan, Francis J. ; Glynn, Sharon A.
Ridge, Sarah M.
Sullivan, Francis J.
Glynn, Sharon A.
Repository DOI
Publication Date
2017-02-01
Keywords
mesenchymal stem cells, tumour microenvironment, cancer progression, tumour metastasis, tumour stroma, tumor-associated macrophages, marrow stromal cells, human bone-marrow, therapy position statement, human prostate-cancer, breast-cancer, adipose-tissue, hematopoietic stem, gastric-cancer, tgf-beta
Type
Article
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Citation
Ridge, Sarah M. Sullivan, Francis J.; Glynn, Sharon A. (2017). Mesenchymal stem cells: key players in cancer progression. Molecular Cancer 16 ,
Abstract
Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem cells (MSCs). MSCs are multipotent stromal cells that are known to reside in various areas such as the bone marrow, fat and dental pulp. MSCs have been found to migrate towards inflammatory sites and studies have shown that they also migrate towards and incorporate into the tumour. The key question is how they interact there. MSCs may interact with tumour cells through paracrine signalling. On the other hand, MSCs have the capacity to differentiate to various cell types such as osteocytes, chondrocytes and adipocytes and it is possible that MSCs differentiate at the site of the tumour. More recently it has been shown that cross-talk between tumour cells and MSCs has been shown to increase metastatic potential and promote epithelial-to-mesenchymal transition. This review will focus on the role of MSCs in tumour development at various stages of progression from growth of the primary tumour to the establishment of distant metastasis.
Funder
Publisher
Springer Nature
Publisher DOI
10.1186/s12943-017-0597-8
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland