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Tolerance checkpoints in b-cell development: johnny b good

Tussiwand, Roxane
; 
Bosco, Nabil
; 
Ceredig, Rhodri
; 
Rolink, Antonius G.
Identifiers
http://hdl.handle.net/10379/14229
 https://doi.org/10.13025/27731
Publication Date
2009-08-27
Keywords
b cells, negative selection, positive selection, receptor editing, tolerance, surrogate-light-chain, heat-stable antigen(hi), pre-b, bone-marrow, lymphocyte development, positive selection, allelic inclusion, autoimmune-disease, escape tolerance, deficient mice
Type
Article
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Citation
Tussiwand, Roxane; Bosco, Nabil; Ceredig, Rhodri; Rolink, Antonius G. (2009). Tolerance checkpoints in b-cell development: johnny b good. European Journal of Immunology 39 (9), 2317-2324
Abstract
B-cell development up to the immature B-cell stage takes place in the bone marrow, while final maturation into mature B cells occurs in the spleen. During differentiation, the precursor and immature B cells have to pass several checkpoints, including those in which they are censored for being auto-reactive, and therefore being potentially dangerous. Numerous studies have shown that the immature B-cell stage in the bone marrow and the transitional B-cell stages in the spleen comprise distinct checkpoints at which auto-reactivity is censored. Recently, evidence has been provided that the large pre-BII stage in the bone marrow, at which the pre-BCR is expressed, is yet another B-cell tolerance checkpoint. Here, we review these findings and speculate on directions for possible further experimentation.
Funder
Publisher
Wiley-Blackwell
Publisher DOI
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
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Externally hosted open access publications with University of Galway authors (2)