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Spontaneous solid-state cocrystallization of caffeine and urea

MacFhionnghaile, Pól
; 
Crowley, Clare M.
; 
McArdle, Patrick
; 
Erxleben, Andrea
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Publication Date
2020-01-09
Keywords
CO-CRYSTALS, PICRIC ACID, PHYSICAL STABILITY, NAPHTHALENE, POLYMORPHS, COMPLEX, PREDICTION, MORPHOLOGY, CHEMISTRY, ADDUCTS
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Article
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Citation
MacFhionnghaile, Pól, Crowley, Clare M., McArdle, Patrick, & Erxleben, Andrea. (2020). Spontaneous Solid-State Cocrystallization of Caffeine and Urea. Crystal Growth & Design, 20(2), 736-745. doi:10.1021/acs.cgd.9b01152
Abstract
The cocrystallization of caffeine and urea was monitored and analyzed using infrared spectroscopy, Raman microscopy, scanning electron microscopy, differential scanning calorimetry, and X-ray diffraction. The caffeine-urea cocrystal was shown to form spontaneously over several weeks under low energy mixing of the solids at room temperature and low relative humidity (
Funder
Science Foundation Ireland
European Regional Development Fund
Publisher
American Chemical Society
Publisher DOI
10.1021/acs.cgd.9b01152
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
Collections
School of Chemistry (Scholarly Articles)