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Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

Kelada, Mark
; 
Walsh, John M D
; 
Devine, Robert W
; 
McArdle, Patrick
; 
Stephens, John C
Identifiers
http://hdl.handle.net/10379/12193
https://doi.org/10.13025/28026
Repository DOI
10.3762/bjoc.14.104
Publication Date
2018-05-28
Keywords
microwave-assisted synthesis, nitrogen-fused heterocycle, one-pot, pyrimidinone, solvent-free conditions, regioselective synthesis, kdm5 inhibitors, identification
Type
Article
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Citation
Kelada, Mark; Walsh, John M D; Devine, Robert W; McArdle, Patrick; Stephens, John C (2018). Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation. Beilstein Journal of Organic Chemistry 14 , 1222-1228
Abstract
A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1, 5-a] pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.
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Publisher
Beilstein Institut
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)