Preparation of imidazo[1,2-c]pyrimidinones from a chloropyrimidine and an electron poor ω-allylic amine
Heaney, Frances ; Bourke, Sharon ; Burke, Cathriona ; Cunningham, Desmond ; McArdle, Patrick
Heaney, Frances
Bourke, Sharon
Burke, Cathriona
Cunningham, Desmond
McArdle, Patrick
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http://hdl.handle.net/10379/9278
https://doi.org/10.13025/24347
https://doi.org/10.13025/24347
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Publication Date
1998-01-01
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Article
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Heaney, Frances; Bourke, Sharon; Burke, Cathriona; Cunningham, Desmond; McArdle, Patrick (1998). Preparation of imidazo[1,2-c]pyrimidinones from a chloropyrimidine and an electron poor ω-allylic amine. Journal of the Chemical Society, Perkin Transactions 1 (15), 2255-2257
Abstract
Synthesis of the title ring system by a sequential intermolecular nucleophilic displacement and intramolecular 'conjugate' addition has been achieved both as a one pot and as a stepwise procedure; an X-ray structure determination has been carried out to distinguish between the possible isomeric structures 8c-I and 8c-II.
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Royal Society of Chemistry (RSC)
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Attribution-NonCommercial-NoDerivs 3.0 Ireland