Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety
O'Halloran, Niamh Courtney, Donald Kerin, Michael Lowery, Aoife
O'Halloran, Niamh
Courtney, Donald
Kerin, Michael
Lowery, Aoife
Identifiers
http://hdl.handle.net/10379/13259
https://doi.org/10.13025/28081
https://doi.org/10.13025/28081
Repository DOI
Publication Date
2017-08-16
Keywords
breast reconstruction, mastectomy, adipose-derived stem cells, tissue engineering, adipose tissue engineering, breast cancer, skin-sparing mastectomy, autologous fat transfer, stromal-vascular fraction, locoregional recurrence risk, promote cancer progression, acellular dermal matrix, acid-based scaffolds, quality-of-life, term-follow-up, extracellular-matrix
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Article
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Citation
O'Halloran, Niamh; Courtney, Donald; Kerin, Michael; Lowery, Aoife (2017). Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety. Breast Cancer: Basic and Clinical Research 11 ,
Abstract
Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.
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Publisher
SAGE Publications
Publisher DOI
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Attribution-NonCommercial-NoDerivs 3.0 Ireland