Wound healing and scar wars
Pugliese, Eugenia Coentro, João Q. Raghunath, Michael Zeugolis, Dimitrios I.
Pugliese, Eugenia
Coentro, João Q.
Raghunath, Michael
Zeugolis, Dimitrios I.
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Repository DOI
Publication Date
2018-06-15
Keywords
Type
Article
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Citation
Pugliese, Eugenia, Coentro, João Q., Raghunath, Michael, & Zeugolis, Dimitrios I. (2018). Wound healing and scar wars. Advanced Drug Delivery Reviews, 129, 1-3. doi: https://doi.org/10.1016/j.addr.2018.05.010
Abstract
Wound healing and scarring are highly conserved physiological responses to wounding in most tissues in higher organisms, consisting of a sequence of well-characterised stages (coagulation, inflammation, proliferation and remodelling [[1], [2], [3]]), with the aim to repair interrupted tissue structures and to restore tissue function [4]. However, this sequence can come to a halt before completion resulting in undesired outcomes, ranging from the formation of a large local scar to organ-encompassing fibrosis. Whilst the former causes cosmetic annoyance, the latter might lead to grave functional impairment or to chronic non-healing wounds.
Funder
Science Foundation Ireland
European Regional Development Fund
Horizon 2020
European Regional Development Fund
Horizon 2020
Publisher
Elsevier
Publisher DOI
10.1016/j.addr.2018.05.010
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland