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Mechanics of human brain organoids

Balbi, Valentina
; 
Destrade, Michel
; 
Goriely, Alain
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Identifiers
http://hdl.handle.net/10379/18072
 https://doi.org/10.13025/15329
Publication Date
2020-01-02
Keywords
Mechanics, human brain organoids
Type
Article
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Citation
Balbi, Valentina, Destrade, Michel, & Goriely, Alain. (2020). Mechanics of human brain organoids. Physical Review E, 101(2), 022403. doi: 10.1103/PhysRevE.101.022403
Abstract
Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs and, in particular, the early morphogenesis of the cortex. Here we propose a mathematical model to elucidate the role played by two mechanisms which have been experimentally proven to be crucial in shaping human brain organoids: the contraction of the inner core of the organoid and the microstructural remodeling of its outer cortex. Our results show that both mechanisms are crucial for the final shape of the organoid and that perturbing those mechanisms can lead to pathological morphologies which are reminiscent of those associated with lissencephaly (smooth brain).
Funder
Engineering and Physical Sciences Research Council
Horizon 2020
Publisher
American Physical Society
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Rights
CC BY-NC-ND 3.0 IE
cbn
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Mathematics (Scholarly Articles)