The collagen suprafamily: From biosynthesis to advanced biomaterial development
Sorushanova, Anna Delgado, Luis M. Wu, Zhuning Shologu, Naledi Kshirsagar, Aniket Raghunath, Rufus Mullen, Anne M. Bayon, Yves Pandit, Abhay Raghunath, Michael
Sorushanova, Anna
Delgado, Luis M.
Wu, Zhuning
Shologu, Naledi
Kshirsagar, Aniket
Raghunath, Rufus
Mullen, Anne M.
Bayon, Yves
Pandit, Abhay
Raghunath, Michael
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Publication Date
2018-08-20
Type
Article
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Citation
Sorushanova, Anna, Delgado, Luis M., Wu, Zhuning, Shologu, Naledi, Kshirsagar, Aniket, Raghunath, Rufus, Mullen, Anne M., Bayon, Yves, Pandit, Abhay, Raghunath, Michael, Zeugolis, Dimitrios I. (2019). The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development. Advanced Materials, 31(1), 1801651. doi:10.1002/adma.201801651
Abstract
Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their respective structures, conformation, and biosynthesis is provided. The advances and shortfalls of various collagen preparations (e.g., mammalian/marine extracted collagen, cell-produced collagens, recombinant collagens, and collagen-like peptides) and crosslinking technologies (e.g., chemical, physical, and biological) are then critically discussed. Subsequently, an array of structural, thermal, mechanical, biochemical, and biological assays is examined, which are developed to analyze and characterize collagenous structures. Lastly, a comprehensive review is provided on how advances in engineering, chemistry, and biology have enabled the development of bioactive, 3D structures (e.g., tissue grafts, biomaterials, cell-assembled tissue equivalents) that closely imitate native supramolecular assemblies and have the capacity to deliver in a localized and sustained manner viable cell populations and/or bioactive/therapeutic molecules. Clearly, collagens have a long history in both evolution and biotechnology and continue to offer both challenges and exciting opportunities in regenerative medicine as nature's biomaterial of choice.
Publisher
Wiley
Publisher DOI
10.1002/adma.201801651
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland