Publication

The yin and yang of nitric oxide in cancer progression

Burke, A. J.
; 
Sullivan, F. J.
; 
Giles, F. J.
; 
Glynn, S. A.
Identifiers
http://hdl.handle.net/10379/10602
https://doi.org/10.13025/28279
Repository DOI
10.1093/carcin/bgt034
Publication Date
2013-01-25
Keywords
human breast-cancer, nonsteroidal antiinflammatory drug, epithelial-mesenchymal transitions, tumor-cell migration, nf-kappa-b, colon-cancer, in-vivo, prostate-cancer, human-melanoma, synthase expression
Type
Article
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Citation
Burke, A. J. Sullivan, F. J.; Giles, F. J.; Glynn, S. A. (2013). The yin and yang of nitric oxide in cancer progression. Carcinogenesis 34 (3), 503-512
Abstract
Nitric oxide (NO) is a short-lived, pleiotropic molecule that affects numerous critical functions in the body. Presently, there are markedly conflicting findings in the literature regarding NO and its role in carcinogenesis and tumor progression. NO has been shown to have dichotomous effects on cellular proliferation, apoptosis, migration, invasion, angiogenesis and many other important processes in cancer biology. It has been shown to be both pro- and antitumorigenic, depending on the concentration and the tumor microenvironment in question. NO is generated by three isoforms of NO synthase (NOS) that are widely expressed and sometimes upregulated in human tumors. Due to its vast array of physiological functions, it presents a huge challenge to researchers to discover its true potential in cancer biology and consequently, its use in anticancer therapies. In this study, we review the current knowledge in this area, with an emphasis placed on NO modulation as an anticancer therapy, focusing on NO-donating drugs and NOS inhibitors.
Funder
Publisher
Oxford University Press (OUP)
Publisher DOI
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)