Factors influencing health-related quality of life in patients with type 1 diabetes
Raymakers, A. J. N. Gillespie, P. O’Hara, M. C. Griffin, M. D. Dinneen, S. F.
Raymakers, A. J. N.
Gillespie, P.
O’Hara, M. C.
Griffin, M. D.
Dinneen, S. F.
Publication Date
2018-02-02
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Article
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Raymakers, A. J. N. Gillespie, P.; O’Hara, M. C.; Griffin, M. D.; Dinneen, S. F. (2018). Factors influencing health-related quality of life in patients with type 1 diabetes. Health and Quality of Life Outcomes 16 ,
Abstract
Aims: Generic, preference-based measures of health-related quality of life (HRQoL) are a common input to the economic evaluation of new health technologies. As such, it is important to explore what characteristics of patients with Type 1 diabetes might impact scores on such measures. Methods: This study utilizes baseline data from a cluster-randomized trial that recruited patients with Type 1 diabetes at six centers across Ireland. Health-related quality of life was assessed using the three-level EuroQol EQ-5D (EQ-5D) measure. Patients' responses to individual dimensions of the EQ-5D were explored. To see which patient factors influenced EQ-5D scores, multivariate regression analysis was conducted with EQ-5D scores as the outcome variable. Results: Data was available for 437 Type 1 diabetes patients. The median age of these patients was 40 (IQR: 31-49) years and 53.8% were female. Overall, patients reported a high HRQoL based on EQ-5D scores (0.87 (SD: 0.19). Fifty-four percent of patients reported a perfect HRQoL. For those that reported problems, the most common dimension was the anxiety/depression dimension of the EQ-5D (29.6%). In the multivariate regression analysis, self-reported mental illness (-0.22 (95% CI: -0.34, -0.10)) and being unemployed (-0.07 (95% CI: -0.13, -0.02)) were negatively associated with EQ-5D scores (p < 0.05). The influence of self-reported mental illness was persistent in sensitivity analyses. Conclusions: The study results indicate that patients with Type 1 diabetes report a high HRQoL based on responses to the EQ-5D. However, there are a substantial number of Type 1 diabetes patients that report problems in the anxiety/depression dimension, which may provide avenues to improve patients' HRQoL.
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Springer Nature
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Attribution-NonCommercial-NoDerivs 3.0 Ireland