Publication

Sensing the difference: the influence of anisotropic cues on cell behavior

Ballester-Beltrán, José
; 
Biggs, Manus J. P.
; 
Dalby, Matthew J.
; 
Salmerón-Sánchez, Manuel
; 
Leal-Egaña, Aldo
Repository DOI
Publication Date
2015-05-08
Keywords
surface topography, anisotropic materials, cell-biomaterial interface, cell-matrix anchorage, topographical cues
Type
Article
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Citation
Ballester-Beltrán, José; Biggs, Manus J. P. Dalby, Matthew J.; Salmerón-Sánchez, Manuel; Leal-Egaña, Aldo (2015). Sensing the difference: the influence of anisotropic cues on cell behavior. Frontiers in Materials ,
Abstract
From tissue morphogenesis to homeostasis, cells continuously experience and respond to physical, chemical, and biological cues commonly presented in gradients. In this article, we focus our discussion on the importance of nano/micro topographic cues on cell activity, and the role of anisotropic milieus play on cell behavior, mostly adhesion and migration. We present the need to study physiological gradients in vitro. To do this, we review different cell migration mechanisms and how adherent cells react to the presence of complex tissue-like environments and cell-surface stimulation in 2D and 3D (e.g., ventral/dorsal anisotropy).
Funder
Publisher
Frontiers Media SA
Publisher DOI
10.3389/fmats.2015.00039
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)