Publication

Progressive fatal myelopathy secondary to isolated spinal cord vasculitis

Fisher, Arie
; 
Rahman, Habib
; 
Farrell, Michael
; 
Hennessy, Michael
Identifiers
http://hdl.handle.net/10379/11478
 https://doi.org/10.13025/28435
Publication Date
2017-12-19
Keywords
primary angiitis of the central nervous system, cns vasculitis, spinal cord vasculitis, spinal cord angiitis, cns angiitis, myelopathy, spinal arteritis, spinal inflammation, central-nervous-system, diagnosis
Type
Article
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Citation
Fisher, Arie; Rahman, Habib; Farrell, Michael; Hennessy, Michael (2017). Progressive fatal myelopathy secondary to isolated spinal cord vasculitis. Frontiers in Neurology 8 ,
Abstract
A 56-year-old woman with various neurological signs which developed over a 1-year period was admitted for evaluation. MRI showed a markedly abnormal signal in the cervical spine. Despite treatment with IV steroids, she developed a progressive myelopathy, became quadriplegic, and required intubation. Immunomodulatory treatment was ineffective. The patient died 24 days after admission. Histopathological investigation revealed spinal cord necrosis with a lymphocyte predominant meningovascular inflammation involving arteries and veins along with evidence of prior occlusive disease of the anterior spinal artery. The changes were confined to the spinal cord. The present case represents an unusual cause of myelitis for which early and aggressive immunomodulatory treatment may have influenced outcomes.
Funder
Publisher
Frontiers Media SA
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)