Publication

Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture

Abbah, Sunny A.
; 
Thomas, Dilip
; 
Browne, Shane
; 
O’Brien, Timothy
; 
Pandit, Abhay
; 
Zeugolis, Dimitrios I.
Identifiers
http://hdl.handle.net/10379/10060
 https://doi.org/10.13025/28457
Publication Date
2016-02-10
Keywords
growth-factor-beta, human skin fibroblasts, cells in-vitro, tgf-beta, tendon repair, differential regulation, patellar tendinopathy, tumor-cells, delivery, collagen
Type
Article
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Citation
Abbah, Sunny A. Thomas, Dilip; Browne, Shane; O’Brien, Timothy; Pandit, Abhay; Zeugolis, Dimitrios I. (2016). Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture. Scientific Reports 6 ,
Abstract
Extracellular matrix synthesis and remodelling are driven by increased activity of transforming growth factor beta 1 (TGF-beta 1). In tendon tissue repair, increased activity of TGF-beta 1 leads to progressive fibrosis. Decorin (DCN) and interleukin 10 (IL-10) antagonise pathological collagen synthesis by exerting a neutralising effect via downregulation of TGF-beta 1. Herein, we report that the delivery of DCN and IL-10 transgenes from a collagen hydrogel system supresses the constitutive expression of TGF-beta 1 and a range of pro-fibrotic extracellular matrix genes.
Funder
Publisher
Springer Nature
Publisher DOI
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)