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Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

Hockman, Dorit
; 
Burns, Alan J
; 
Schlosser, Gerhard
; 
Gates, Keith P
; 
Jevans, Benjamin
; 
Mongera, Alessandro
; 
Fisher, Shannon
; 
Unlu, Gokhan
; 
Knapik, Ela W
; 
Kaufman, Charles K
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Identifiers
http://hdl.handle.net/10379/11944
https://doi.org/10.13025/28483
Repository DOI
10.7554/elife.21231
Publication Date
2017-04-07
Keywords
pulmonary neuroendocrine cells, gill neuroepithelial cells, neural crest contributions, mammalian carotid-body, xenopus-laevis, arterial chemoreceptors, progenitor cells, catecholamine response, oxygen chemoreceptors, zebrafish cornea
Type
Article
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Citation
Hockman, Dorit; Burns, Alan J; Schlosser, Gerhard; Gates, Keith P; Jevans, Benjamin; Mongera, Alessandro; Fisher, Shannon; Unlu, Gokhan; Knapik, Ela W; Kaufman, Charles K; Mosimann, Christian; Zon, Leonard I; Lancman, Joseph J; Dong, P Duc S; Lickert, Heiko; Tucker, Abigail S; Baker, Clare V H (2017). Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. eLife 6 ,
Abstract
The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes carotid body glomus cells, and 'pulmonary neuroendocrine cells' (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive 'neuroepithelial cells' (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.
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Publisher
eLife Sciences Organisation, Ltd.
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)