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A biocatalytic cascade with several output signals—towards biosensors with different levels of confidence

Guz, Nataliia
; 
Halámek, Jan
; 
Rusling, James F.
; 
Katz, Evgeny
Identifiers
http://hdl.handle.net/10379/11780
 https://doi.org/10.13025/28534
Publication Date
2014-04-20
Keywords
bioanalytical methods, bioassays, enzymes, optical sensors, biocomputing, logic gates, logic gates, molecular logic, computation
Type
Article
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Citation
Guz, Nataliia; Halámek, Jan; Rusling, James F. Katz, Evgeny (2014). A biocatalytic cascade with several output signals—towards biosensors with different levels of confidence. Analytical and Bioanalytical Chemistry 406 (14), 3365-3370
Abstract
The biocatalytic cascade based on enzyme-catalyzed reactions activated by several biomolecular input signals and producing output signal after each reaction step was developed as an example of a logically reversible information processing system. The model system was designed to mimic the operation of concatenated AND logic gates with optically readable output signals generated at each step of the logic operation. Implications include concurrent bioanalyses and data interpretation for medical diagnostics.
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Publisher
Springer Nature
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)