Recent advances in psychoneuroimmunology: inflammation in psychiatric disorders
Debnath, Monojit Doyle, Karen M. Langan, Camilla McDonald, Colm Leonard, Brian Cannon, Dara
Debnath, Monojit
Doyle, Karen M.
Langan, Camilla
McDonald, Colm
Leonard, Brian
Cannon, Dara
Publication Date
2011-01-01
Keywords
inflammation, cytokines, etiology, psychiatric disorders, neurotransmitter imbalance, maternal infections, apoptosis, brain derived neurotrophic factor, hypothalamic pituitary adrenal axis, glutamate, dopamine, serotonin, quinolinic acid, kynurenic acid, major depressive disorder, necrosis-factor-alpha, central-nervous-system, acute-phase proteins, c-reactive protein, factor-kappa-b, bipolar affective-disorder, oxide synthase expression, induced sickness behavior, traumatic brain-injury
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Article
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Citation
Debnath, Monojit; Doyle, Karen; Langan, Camilla; McDonald, Colm; Leonard, Brian; Cannon, Dara (2011). Recent advances in psychoneuroimmunology: inflammation in psychiatric disorders. Translational Neuroscience 2 (2), 121-137
Abstract
Psychiatric disorders are common and complex and their precise biological underpinnings remain elusive. Multiple epidemiological, molecular, genetic and gene expression studies suggest that immune system dysfunction may contribute to the risk for developing psychiatric disorders including schizophrenia, bipolar disorder, and major depressive disorder. However, the precise mechanisms by which inflammation-related events confer such risk are unclear. In this review, we examine the peripheral and central evidence for inflammation in psychiatric disorders and the potential molecular mechanisms implicated including inhibition of neurogenesis, apoptosis, the HPA-axis, the role of brain-derived neurotrophic factor and the interplay between the glutamatergic, dopaminergic and serotonergic neurotransmitter systems.
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Publisher
Walter de Gruyter GmbH
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Attribution-NonCommercial-NoDerivs 3.0 Ireland