Publication

Ecdysonelactones, ecdysteroids from the tropical eastern pacific zoantharian antipathozoanthus hickmani

Guillen, Paul
; 
Calabro, Kevin
; 
Jaramillo, Karla
; 
Dominguez, Cristobal
; 
Genta-Jouve, Grégory
; 
Rodriguez, Jenny
; 
Thomas, Olivier
Identifiers
http://hdl.handle.net/10379/11751
https://doi.org/10.13025/28719
Repository DOI
10.3390/md16020058
Publication Date
2018-02-11
Keywords
ecdysteroids, ecdysonelactones, gamma-lactone, zoantharia, relative configuration, cnidaria, marine zoanthid, parazoanthus sp, hexacorallia, alkaloids, phytoecdysteroids, zoanthamine, anthozoa, islands, reptans, roots
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Article
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Citation
Guillen, Paul; Calabro, Kevin; Jaramillo, Karla; Dominguez, Cristobal; Genta-Jouve, Grégory; Rodriguez, Jenny; Thomas, Olivier (2018). Ecdysonelactones, ecdysteroids from the tropical eastern pacific zoantharian antipathozoanthus hickmani. Marine Drugs 16 (2),
Abstract
Despite a large occurrence, especially over the Pacific Ocean, the chemical diversity of marine invertebrates belonging to the order Zoantharia is largely underexplored. For the two species of the genus Antipathozoanthus no chemical study has been reported so far. The first chemical investigation of Antipathozoanthus hickmani collected at the Marine Protected Area El Pelado, Santa Elena, Ecuador, led to the isolation of four new ecdysteroid derivatives named ecdysonelactones. The structures of ecdysonelactones A-D (1-4) were determined based on their spectroscopy data, including 1D and 2D NMR and HRMS. The four compounds of this family of ecdysteroids feature an unprecedented -lactone fused at the C-2/C-3 position of ring A. These derivatives exhibited neither antimicrobial nor cytotoxic activities.
Funder
Publisher
MDPI AG
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)