Publication

Overexpression of wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development

Zhu, Xuming
Wu, Yumei
Huang, Sixia
Chen, Yingwei
Tao, Yixin
Wang, Yushu
He, Shigang
Shen, Sanbing
Wu, Ji
Guo, Xizhi
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Citation
Zhu, Xuming; Wu, Yumei; Huang, Sixia; Chen, Yingwei; Tao, Yixin; Wang, Yushu; He, Shigang; Shen, Sanbing; Wu, Ji; Guo, Xizhi; Li, Baojie; He, Lin; Ma, Gang (2014). Overexpression of wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development. Experimental Dermatology 23 (12), 926-928
Abstract
Increased Wnt5a expression has been observed in psoriatic plaques. However, whether Wnt5a overexpression directly causes psoriasis is unknown. In this study, we generated transgenic (TG) mice with epidermal Wnt5a overexpression under the control of the human K14 promoter. The skin of Wnt5a TG mice was not psoriatic, but characterized with normal proliferation and homeostasis of epidermis. Instead, these TG mice displayed impaired hair follicle transition from telogen to anagen, most likely due to impaired canonical Wnt signalling. These results suggest that increased Wnt5a expression alone is inadequate to induce psoriasis in the skin and possible involvement of Wnt5a in hair follicle cycling.
Funder
Publisher
Wiley-Blackwell
Publisher DOI
10.1111/exd.12539
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland