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Brief report: glutamate transporter gene (slc1a1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder

Gadow, Kenneth D.
; 
Roohi, Jasmin
; 
DeVincent, Carla J.
; 
Kirsch, Sarah
; 
Hatchwell, Eli
Identifiers
http://hdl.handle.net/10379/12969
 https://doi.org/10.13025/28839
Publication Date
2010-02-13
Keywords
assessment, relations, relational frame theory, correlation, vineland, generativity, infant
Type
journal article
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Citation
Gadow, Kenneth D. Roohi, Jasmin; DeVincent, Carla J.; Kirsch, Sarah; Hatchwell, Eli (2010). Brief report: glutamate transporter gene (slc1a1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder. Journal of Autism and Developmental Disorders 40 (9), 1149-1153
Abstract
Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive-compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.
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Publisher
Springer Nature
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Externally hosted open access publications with University of Galway authors (2)