Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia
Donohoe, Gary Frodl, Thomas Morris, Derek Spoletini, Ilaria Cannon, Dara M. Cherubini, Andrea Caltagirone, Carlo Bossù, Paola McDonald, Colm Gill, Michael
Donohoe, Gary
Frodl, Thomas
Morris, Derek
Spoletini, Ilaria
Cannon, Dara M.
Cherubini, Andrea
Caltagirone, Carlo
Bossù, Paola
McDonald, Colm
Gill, Michael
Publication Date
2009-09-30
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Article
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Donohoe, Gary; Frodl, Thomas; Morris, Derek; Spoletini, Ilaria; Cannon, Dara M; Cherubini, Andrea; Caltagirone, Carlo; Bossù, Paola; McDonald, Colm; Gill, Michael; Corvin, Aiden P; Spalletta, Gianfranco (2009). Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia. Neuropsychopharmacology 35 (2), 368-373
Abstract
A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry, whole-volume analysis revealed significantly reduced GMVs in both the right dorsolateral prefrontal and left occipital cortex, corresponding to the behavioral findings of impaired spatial working memory and EEG findings of impaired visual processing already reported. These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased. Neuropsychopharmacology (2010) 35, 368-373; doi: 10.1038/npp.2009.140; published online 30 September 2009
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Springer Nature
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Attribution-NonCommercial-NoDerivs 3.0 Ireland