Publication

Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and lc-ms/ms

Li, Dandan
; 
Fu, You-Jun
; 
Rusling, James F.
Identifiers
http://hdl.handle.net/10379/12441
 https://doi.org/10.13025/28910
Publication Date
2015-01-01
Keywords
glutathione-s-transferase, induced hepatic-necrosis, mass-spectrometry, covalent binding, toxicity, acetaminophen, mechanisms, drug, electrophiles, paracetamol
Type
Article
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Citation
Li, Dandan; Fu, You-Jun; Rusling, James F. (2015). Characterizing protein modifications by reactive metabolites using magnetic bead bioreactors and lc-ms/ms. Chem. Commun. 51 (22), 4701-4703
Abstract
We report here label-free metabolite-protein adduct detection and identification employing magnetic beads coated with metabolic enzymes as bioreactors to generate metabolites and possible metabolite-protein adducts for analysis by liquid chromatographytandem mass spectrometry.
Funder
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)