Ganglioside gm1 mimicry incampylobacterstrains from sporadic infections in the united states
Nachamkin, Irving Ung, Huong Moran, Anthony P. Yoo, Dale Prendergast, Martina M. Nicholson, Mabel A. Sheikh, Kazim Ho, Tony Asbury, Arthur K. McKhann, Guy M.
Nachamkin, Irving
Ung, Huong
Moran, Anthony P.
Yoo, Dale
Prendergast, Martina M.
Nicholson, Mabel A.
Sheikh, Kazim
Ho, Tony
Asbury, Arthur K.
McKhann, Guy M.
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Publication Date
1999-05-01
Type
Article
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Citation
Nachamkin, Irving; Ung, Huong; Moran, Anthony P. Yoo, Dale; Prendergast, Martina M.; Nicholson, Mabel A.; Sheikh, Kazim; Ho, Tony; Asbury, Arthur K.; McKhann, Guy M.; Griffin, John W. (1999). Ganglioside gm1 mimicry incampylobacterstrains from sporadic infections in the united states. The Journal of Infectious Diseases 179 (5), 1183-1189
Abstract
To determine whether GM1-like epitopes in Campylobacter species are specific to O serotypes associated with Guillain-Barre syndrome (GBS) or whether they are frequent among random Campylobacter isolates causing enteritis, 275 random enteritis-associated isolates of Campylobacter jejuni were analyzed. The isolates were collected in the United States using a cholera toxin-binding assay. Overall, 26.2% of the isolates were positive for the GM1-like epitope. Of the 36 different O serotypes in the sample, 21 (58.3%) contained no strains positive for GM1, whereas in 6 serotypes (16.7%), >50% of isolates were positive for GM1. GBS-associated serotypes were more likely to contain strains positive for GM1 than were non-GBS-associated serotypes (37.8% vs. 15.1%, P = .0116). The results suggest that humans are frequently exposed to strains exhibiting GM1-like mimicry and, while certain serotypes may be more likely to possess GM1-like epitopes, the presence of GM1-like epitopes on Campylobacter strains does not itself trigger GBS.
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Publisher
Oxford University Press (OUP)
Publisher DOI
10.1086/314725
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Attribution-NonCommercial-NoDerivs 3.0 Ireland