Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th biennial hatter cardiovascular institute workshop
Pickard, Jack M. J. Bøtker, Hans Erik Crimi, Gabriele Davidson, Brian Davidson, Sean M. Dutka, David Ferdinandy, Peter Ganske, Rocky Garcia-Dorado, David Giricz, Zoltan
Pickard, Jack M. J.
Bøtker, Hans Erik
Crimi, Gabriele
Davidson, Brian
Davidson, Sean M.
Dutka, David
Ferdinandy, Peter
Ganske, Rocky
Garcia-Dorado, David
Giricz, Zoltan
Identifiers
http://hdl.handle.net/10379/13468
https://doi.org/10.13025/28924
https://doi.org/10.13025/28924
Repository DOI
Publication Date
2014-12-02
Keywords
ischemia, organ protection, remote ischemic conditioning, reperfusion, randomized controlled-trial, bypass graft-surgery, percutaneous coronary intervention, elevation myocardial-infarction, acute kidney injury, reperfusion injury, preconditioning protects, induced nephropathy, cellular biology, european-society
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Article
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Citation
Pickard, Jack M. J. Bøtker, Hans Erik; Crimi, Gabriele; Davidson, Brian; Davidson, Sean M.; Dutka, David; Ferdinandy, Peter; Ganske, Rocky; Garcia-Dorado, David; Giricz, Zoltan; Gourine, Alexander V.; Heusch, Gerd; Kharbanda, Rajesh; Kleinbongard, Petra; MacAllister, Raymond; McIntyre, Christopher; Meybohm, Patrick; Prunier, Fabrice; Redington, Andrew; Robertson, Nicola J.; Suleiman, M. Saadeh; Vanezis, Andrew; Walsh, Stewart; Yellon, Derek M.; Hausenloy, Derek J. (2014). Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th biennial hatter cardiovascular institute workshop. Basic Research in Cardiology 110 (1),
Abstract
In 1993, Przyklenk and colleagues made the intriguing experimental observation that 'brief ischemia in one vascular bed also protects remote, virgin myocardium from subsequent sustained coronary artery occlusion' and that this effect '.... may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemia/reperfusion'. This seminal study laid the foundation for the discovery of 'remote ischemic conditioning' (RIC), a phenomenon in which the heart is protected from the detrimental effects of acute ischemia/reperfusion injury (IRI), by applying cycles of brief ischemia and reperfusion to an organ or tissue remote from the heart. The concept of RIC quickly evolved to extend beyond the heart, encompassing inter-organ protection against acute IRI. The crucial discovery that the protective RIC stimulus could be applied non-invasively, by simply inflating and deflating a blood pressure cuff placed on the upper arm to induce cycles of brief ischemia and reperfusion, has facilitated the translation of RIC into the clinical setting. Despite intensive investigation over the last 20 years, the underlying mechanisms continue to elude researchers. In the 8th Biennial Hatter Cardiovascular Institute Workshop, recent developments in the field of RIC were discussed with a focus on new insights into the underlying mechanisms, the diversity of non-cardiac protection, new clinical applications, and large outcome studies. The scientific advances made in this field of research highlight the journey that RIC has made from being an intriguing experimental observation to a clinical application with patient benefit.
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Publisher
Springer Nature
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Attribution-NonCommercial-NoDerivs 3.0 Ireland