Long-term outcome of patients with mutiple myeloma-related advanced renal failure following auto-sct
Glavey, S V Gertz, M A Dispenzieri, A Kumar, S Buadi, F Lacy, M Hayman, S R Dingli, D McCurdy, A Hogan, W J
Glavey, S V
Gertz, M A
Dispenzieri, A
Kumar, S
Buadi, F
Lacy, M
Hayman, S R
Dingli, D
McCurdy, A
Hogan, W J
Publication Date
2013-08-05
Type
Article
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Citation
Glavey, S V; Gertz, M A; Dispenzieri, A; Kumar, S; Buadi, F; Lacy, M; Hayman, S R; Dingli, D; McCurdy, A; Hogan, W J; Gastineau, D A; Leung, N (2013). Long-term outcome of patients with mutiple myeloma-related advanced renal failure following auto-sct. Bone Marrow Transplantation 48 (12), 1543-1547
Abstract
Renal failure commonly complicates multiple myeloma (MM) and is associated with reduced survival. It is not clear whether auto-SCT results in improved renal function or attainment of independence from dialysis in patients with advanced renal impairment due to MM. We conducted a retrospective cohort study of all patients who underwent auto-SCT for MM complicated by advanced renal failure at our institution over a 10-year period (2000-2010). We aimed to assess the association between auto-SCT and renal outcome in patients with serum creatinine (SCr) over >3 mg/dL, attributable to MM, including those who were dialysis dependent. Thirty patients (2.8% of all auto-SCT patients) met inclusion criteria. Fourteen of 15 patients who were dialysis dependent before auto-SCT remained dialysis dependent in the long term despite hematological response (HR). Of the remaining 15 patients with SCr 43 mg/dL, an improvement in glomerular filtration rate (GFR) from 15 to 19.4 mL/min/1.73 m(2) was noted post auto-SCT (P = 0.035); however, neither HR post auto-SCT or pre-existing renal function were independently associated with renal outcome. Auto-SCT was not associated with independence from dialysis in patients with renal failure due to MM at our institution. Although auto-SCT was associated with an improvement in GFR in patients with SCr 43 mg/dL, this improvement was not related to HR.
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Springer Nature
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Attribution-NonCommercial-NoDerivs 3.0 Ireland