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New cyclometalated ir(iii) complexes with ncn pincer and meso-phenylcyanamide bodipy ligands as efficient photodynamic therapy agents

Tabrizi, Leila
; 
Chiniforoshan, Hossein
Identifiers
http://hdl.handle.net/10379/14108
 https://doi.org/10.13025/29018
Publication Date
2017-01-01
Keywords
cancer-cells, iridium(iii) complexes, polypyridyl complexes, nickel(ii) complexes, anticancer agents, arene complexes, metal-complexes, cellular uptake, visible-light, photosensitizers
Type
Article
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Citation
Tabrizi, Leila; Chiniforoshan, Hossein (2017). New cyclometalated ir(iii) complexes with ncn pincer and meso-phenylcyanamide bodipy ligands as efficient photodynamic therapy agents. RSC Advances 7 (54), 34160-34169
Abstract
A new class of cyclometalated iridium((III)) with NCN pincer and meso-phenylcyanamide BODIPY ligands of the formula [Ir(L)(PPY)(Pcyd-BODIPY)], 1, [Ir(L)(PIQ)(Pcyd-BODIPY)], 2, in which HL: 5-methoxy-1,3-bis (1-methyl-1H-benzo[d]imidazol-2-yl) benzene, Pcyd-BODIPY: 8-(4-phenylcyanamide) BODIPY, PPY: 2-phenylpyridine, PIQ: 1-phenylisoquinoline have been synthesized and studied for photodynamic therapy (PDT). The photophysical properties, DNA binding, DNA photocleavage, cellular uptake, thioredoxin reductase activity, reactive oxygen species (ROS) generation, and cellular apoptosis of the complexes have also been studied. Therefore, we present a conceivable biologically applicable PDT modality that develops persuasively designed photoactivatable Ir((III)) complexes.
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Publisher
Royal Society of Chemistry (RSC)
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)