Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal
Doyle, Heather Lohfeld, Stefan Durselen, Lutz McHugh, Peter
Doyle, Heather
Lohfeld, Stefan
Durselen, Lutz
McHugh, Peter
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Repository DOI
Publication Date
2015-01-14
Keywords
Orthopaedic scaffold, PCL, Critical sized defect, Defect stability, Beta-tricalcium phosphate, β-tricalcium phosphate, External fixator, Quantitative computed tomography, Fracture healing process, Finite element analysis, Mechanical properties, Distraction osteogenesis, Composite scaffolds, Contact forces, Bone, Hydroxyapatite, Regeneration
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Article
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Citation
Doyle, Heather, Lohfeld, Stefan, Dürselen, Lutz, & McHugh, Peter. (2015). Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal. Journal of the Mechanical Behavior of Biomedical Materials, 44, 133-146. doi: http://dx.doi.org/10.1016/j.jmbbm.2015.01.008
Abstract
Computational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the real in vivo defects. Simulations of each defect under four-point bending and under simulated in vivo axial compressive loading are performed. The mechanical stability of each defect is analysed using stress distribution analysis. The results of this analysis highlights the influence of callus volume, and both scaffold volume and stiffness, on the load-bearing abilities of these defects. Clinically-used image-based methods to predict the safety of removing external fixation are evaluated for each defect. Comparison of these measures with the results of computational analyses indicates that care must be taken in the interpretation of these measures.
Funder
Publisher
Elsevier
Publisher DOI
10.1016/j.jmbbm.2015.01.008
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland